Requirements for the moisture content of the desiccant in the effervescent tube

Effervescent tube is a kind of pharmaceutical packaging container with excellent moisture-proof performance. On the one hand, its moisture-proof function is realized through strict sealing. On the other hand, silica gel and molecular sieve desiccant are placed inside the package to absorb the internal moisture.

144mm*29mm effervescent tube packaging

For the moisture content of the two desiccants, effervescent tubes also have relevant regulations. In YBB00172004-2015 "Quality Standard for Oral Solid Pharmaceutical Low Density Polyethylene Moisture-Proof Combination Caps", the requirements for the moisture content of the desiccant are as follows:

caps for effervescent tube

In an environment where the relative humidity of silica gel does not exceed 75%, quickly take out the bottle cap from the closed packaging bag, and take out 5-7g of desiccant from the bottle cap, put it in a weighing bottle (W1) with constant weight, and weigh it. Weight (W2), placed in an oven at 180°C ± 10°C (the total time from opening the bottle cap to the time when the desiccant is placed in the oven should not exceed 5 minutes) to constant weight (weighing as W3), calculated by the following formula, containing water The rate must not exceed 4.8%.

Macromolecular sieve In an environment where the relative humidity does not exceed 75%, quickly take out an appropriate amount of the bottle cap from the closed package, take out the desiccant in the bottle cap with tweezers, and place it in a constant weight crucible W0 (add 8-10g to each crucible). ), accurately weighed W1, placed in a high-temperature furnace at 950°C (the total time from opening the cap packaging bag to placing the desiccant in the high-temperature furnace should not exceed 5 minutes), drying for one hour, taking out the crucible, and accurately weighing after cooling. Determine W2, and calculate according to the following formula, and the moisture content should not exceed 4.8%.

The above are the requirements of the effervescent tube for the moisture content of the desiccant. A qualified desiccant is the basis for ensuring its internal moisture-proof performance and is also an important factor to ensure the stability of the effervescent tablet.