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Comparison of barrier detection methods for pharmaceutical packaging materials

Jul 16 , 2019

The output of plastic packaging materials and products for pharmaceuticals is growing rapidly. New materials, new processes, new technologies and new products are constantly emerging, which greatly improves the packaging status of pharmaceuticals. Among them, barrier properties are always one of the important indicators of packaging materials. Practice has proved that the use of high barrier packaging materials can effectively improve the quality of preservation of drugs, and can prevent the deterioration of drugs during the shelf life.


Comparison of barrier detection methods for pharmaceutical packaging materials

effervescent tablet packaging

Therefore, high-barrier packaging materials such as effervescent tablets, test strip packaging, HDPE bottles, etc. are rapidly spread and applied on the medicine package. However, at present, there is a large randomness in the choice of experimental methods for barrier properties of packaging materials in the field of drug packaging in China. Different test methods will produce different test results, which will undoubtedly affect the correct selection of pharnaceutical packaging materials, so it is necessary for the country to regulate the detection method of drug packaging materials. Considering material selection and performance comparison, the relevant standard YBB008-2003 "Gas Permeability Measurement Method" and YBB0009-2003 "Water Vapor Permeation Measurement Method".


Comparison of barrier detection methods for pharmaceutical packaging materials

test strip packaging


YBB0008-2003 "Gas Permeability Measurement Method" further specifies the method for determining the gas permeation amount in the product standard for plastic pharmaceutical bottles. The gas permeability test mentioned above also becomes a gas barrier test, a gas barrier test or a gas permeability test. It is mainly used to examine the barrier properties of thin films and flakes to common inorganic gases. 


Comparison of barrier detection methods for pharmaceutical packaging materials  

child proof bottle

The gas permeability test method is convenient for practical operation, and is suitable for drug packaging, composite film for pharmaceutical packaging, medicinal film, multi-layer co-infusion film, composite medicinal ointment, etc. And electricity analysis. Since the two methods cannot be completely described by the same model in the test principle, the test state of the sample under these two test methods is not completely the same, so the test of the same sample under the two test methods is not performed. The data was quantified.

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