In the cutting-edge fields of cell therapy and gene medicine, every vial of cell-based preparation—each carrying the hope of life—faces formidable storage challenges.
While ultra-low temperature preservation in liquid nitrogen can effectively halt cellular metabolism, it imposes extremely stringent requirements on packaging materials. With its breakthrough material science and performance advantages, COP (Cyclic Olefin Polymer) vials create an unbreakable cold-chain fortress for these high-value drugs, becoming the trusted choice in the biopharmaceutical industry.
Polymer Vial 2ml 5ml 10ml for cell and gene therapies
1. The Core Challenges of Low-Temperature Storage: Three Key Performance Tests
Storing cell-based drugs in liquid nitrogen (−196°C) subjects packaging to three extreme tests:
Protein adsorption: This directly affects drug activity. Traditional containers may lead to the loss of valuable protein components.
Cryogenic durability: Material integrity is critical. Common materials tend to crack or leak at ultra-low temperatures.
Chemical stability: Safety is paramount. If harmful substances are released during sterilization, it can cause irreversible contamination.
2. Material Innovation: Four Protective Barriers of COP Vials
The introduction of COP material has revolutionized the storage of cell-based drugs:
Liquid nitrogen-grade cryo-resistance: COP’s unique molecular structure gives it exceptional flexibility. Even at −196°C, it retains strong mechanical integrity. After repeated freeze-thaw cycles, vials show no cracking or deformation, effectively eliminating leakage risks.
Near-zero adsorption surface: The smooth, inert surface of COP reduces protein adsorption by over 90% compared to traditional materials.
Sterilization-safe chemical stability: COP can withstand high-intensity sterilization methods like gamma irradiation and electron beam without degrading or releasing harmful substances. It is certified for biocompatibility under ISO 10993, adding double assurance to drug safety.
Long-lasting airtight protection: With precisely engineered neck design and a tight-fitting rubber stopper and aluminum seal, COP vials maintain excellent airtightness even under extreme cold, preventing moisture ingress and drug damage caused by freeze-related crystallization.
3. End-to-End Protection: Reliable from Storage to Transport
COP vials deliver value not only in long-term storage but also throughout the entire drug logistics process. During cold chain transport, they withstand rapid temperature changes from −80°C to −196°C due to their outstanding impact resistance. Their small-volume formats support accurate dosing in clinical settings, reducing waste. The transparent vial design allows real-time monitoring of drug status, meeting the needs of both research and production environments.
4. Customizable Solutions: Tailored for Diverse Applications
To meet the diverse needs of the biopharmaceutical industry, Xinfuda offers comprehensive customization services—from full-volume ranges (2ml to 100ml) to tailored neck diameters and cap types—allowing packaging to be precisely matched to the characteristics of each drug.
As cell-based drugs pave the way for the future of medicine, COP vials stand as a technological shield safeguarding every hope for life. Whether it’s a precious research sample in a laboratory or a soon-to-be-launched innovative therapy, COP vials ensure drug safety with top-tier performance.
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