Glass bottle adsorption protein

my country's modern biotechnology represented by genetic engineering, cell engineering, enzyme engineering, etc. has developed rapidly, and the complexity and sensitivity of biopharmaceuticals have also changed. As a result, glass, a conventional bottle material, cannot fully meet the needs of high-end pharmaceutical packaging. In this context, high-end pharmaceutical packaging such as COP bottles ushered in development opportunities.

COP vial

The glass material has protein adsorption properties, and the attachment of drugs on the glass surface will reduce the utilization rate of the drugs in the packaging. This means that pharmaceutical companies need to overfill the drugs to compensate for product losses, which will adversely affect production efficiency and manufacturing costs. To solve the problem of protein adsorption, you can reduce the adsorption by adding high-concentration inert protein to the drug formulation or treating the glass surface with silicone oil. However, the drug formulation data is rigorous, and a little carelessness will have a certain impact on the efficacy of the drug. Therefore, it is an ideal way to solve the problem of protein adsorption by changing the way of packaging materials.

At present, a high-quality packaging with low protein adsorption, low refractive index, and drug compatibility test without peeling has been widely used abroad, that is, cycloolefin polymer (COP). Compared with glass materials, this material has higher transparency and can be used for drugs with PH greater than 9, such as Avastin, alemtuzumab, opdivo, primima, etanercept and other lymphocyte antigens Drugs such as anti-tumor and anti-tumor drugs are packaged in COP bottles.

Although the price is higher than that of glass materials, COP bottles can effectively reduce the drug adsorption on the surface of the container and improve the utilization rate of the drugs, thereby saving very expensive biological drug overflow costs. From this point of view, it should be enough to offset the higher COP plastic bottle cost.